ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF DICLOFENAC SODIUM BY SOLID DISPERSION METHOD

Diclofenac sodium (Poorly water soluble drug), when prepared as solid dispersion showed improved solubility and dissolution. So the main purpose of this investigation was to increase the solubility and dissolution rate of Diclofenac sodi um by the preparation of its solid dispersion with polyvinyl pyrrolidone using solvent evaporation method. It is necessary to improve the solubility and bio availability of poorly water soluble drugs. There are many techniques that have commonly been used to improve solubility and bio availability. The term solid dispersions refer to the dispersion of one or more active ingredients in an inert carrier or matrix at solid state prepared by solvent evaporation. Polyvinyl pyrrolidone is most commo nly used as carrier in the solid dispersion system. The effect of the carrier on the solubility and dissolution were studied. The carrier used for the preparation of solid dispersion showed significant increase in the solubility of diclofenac sodium