OPTIMIZATION OF PRODUCT VARIABLES IN FORMULATION OF METOPROLOL TARTARATE MICROBEADS

The objective of this study the effect of product variables like polymer and cross linking agent in Formulation and Evaluation microbeads containing Metoprolol tartarate for the treatment of Hypertension. Five formulation of microbeads are prepared by Ionotrophic gelation method by using different concentration o f sodium alginate natural polymer and calcium chloride cross linking agent. The Cacl 2 was used as a cross linking agent to stabilize the microbeads and to enhance the drug entrapment efficiency and matrix formation of microbeads while processing the formulation. In process optimization techniques are followed to select an optimized concentration of polymer and cross linking agent in the formulation of Microbeads. The formulated microbeads are inspected for surface morphology by SEM studies, Drug content, en trapment efficiency, and Invitro drug release studies etc.