FORMULATION OF CANDESARTAN CILEXETIL TRANSDERMAL PATCHES IN-VITRO AND EX-VIVO CHARACTERIZATION

The Aim of this investigation was to develop and evaluate transdermal drug delivery systems of Candesartan Cilexetil. These patches were prepared by solvent evaporation technique. Twelve formulations composed of HPMC E 15cps, EC, PVP in different ratios were formulated i.e, HPMC:EC in three ratios 1:1, 2:1,4:1 and HPMC:PVP in three ratios 1:1, 2:1, 4:1 ratios these are named from F1 to F6. Same formulations are added with 6% DMSO as penetration enhancer and named from F7 to F12. All the formulations carried 15% Propylene glycol as plasticizer. The maximum % drug release in 24hrs for F12 formulation was 96.1±2.14 and showed maximum skin permeation 819.2±7.76µg/cm 2 in respective series and found to have required flux. The drug permeation kinetics followed Zero ord er profile with diffusion mechanism. The results indicate that Candesartan Cilexetil Transdermal patches could be prepared with the required flux having suitable mechanical properties.