FORMULATION AND EVALUATION OF RIZATRIPTAN BENZOATE ORAL DISPERSIBLE TABLETS

RZT is potent anti migraine drug having agonist activity at the 5-hydroxytryptamine (5-HT) 1B and 5-HT1D receptor. It commonly used for relief of headaches in treatment of migraine. Conventional tablets of RZT are not capable of rapid actio n, which is required for immediate relief from migraine pain. Marketed freeze dried tablet of RZT is available. Freeze drying is cumbersome and it yields a fragile and hygroscopic product. Thus, the aim of the present investigation is to formulate orally disintegrating tablets (ODTs) of Rizatriptan using simple and cost effective dosage forms. Approach used was use of superdisintegrants to prepare tablets. Tablets were prepared by direct compression using super disintegrants such crospovidone, croscarmellose sodium, and sodium starch glycolate with incorporation of diluents like lactose, MCC and mannit ol. Tablets of RZT prepared using crospovidone with MCC exhibited the least friability and disintegration time (s). To decrease the disintegration time further, modified diluents like spray dried lactose, Avicel PH 102 and Orocell 200.used along with the superdisintegrants for the preparation of ODTs. Tablet prepared using orocell showed good disintegration but shows less dispersion. Further trial was done in combinations of Orocell with Avicel PH 102. Among them Avicel PH 102 and orocell in 35:65 ratio showed less time of disintegration and rapid dissolution.