SELF-MICROEMULSIFYING: A NEW APPROACH OF LIPID BASED DRUG DELIVERY SYSTEMS

Md. Mehdi Hasan
Department of Pharmacy, Faculty of Health science, Northern University Bangladesh, Dhaka -1205, Bangladesh
Md.Mizanur Rahman
Department of Pharmacy, Stamford University Bangladesh, Dhaka-1217, Bangladesh.
Mahbub Hasan
Department of Pharmacy, Stamford University Bangladesh, Dhaka-1217, Bangladesh.
S.M. Nazrul Islam
Department of Pharmaceutical Sciences, School of Health & life sciences, North South University, Dhaka-1229, Bangladesh.
Masum Al Hasan
Department of Pharmacy, Faculty of Health science, Northern University Bangladesh, Dhaka -1205, Bangladesh
Harun Ar Rashid
Department of Pharmacy, Faculty of Health science, Northern University Bangladesh, Dhaka -1205, Bangladesh

Bioavailability ,Lipid based drug delivery system ,Lymphatic transport and Self micro -emulsifying drug ,Drug absorption Lipid excipients ,Surfactant ,Evaluation ,Zeta potential ,

Solubility is one of the key factor in drug formulation in order to ensure better bioavailability. As 40% of new drugs are poorly soluble, it has become a matter of concern and challenge for the formulation scientists with regard to solubility and bioavailability. Though formulation approac hes like solid dispersions, complexation, pH modification exist, but there are areas of further research and development for better approaches. Lipid-based drug delivery systems (LBDDS) are one of the emerging technologies designed to address such challenges in recent time. These systems have shown great promise which can lead to increased solubilization and absorption, resulting in enhanced bioavailability. This review provides a comprehensive understandings of Lipid -based drug delivery systems especially for oral delivery, from both physicochemical and biopharmaceutical perspectives. This review also focuses on advanced techniques and processes, along with a brief discussion of various lipid excipients and their characterization.

7 , 1 , 2017