EVALUATION OF ANTIFUNGAL ACTIVITY OF FLUCONAZOLE AND CINNAMON OIL BASED NANO-EMULSION
Atish Khilari
Department of Pharmaceutics, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-411044, India.
Mukesh Mohite
Department of Pharmaceutics, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-411044, India.
Pavan Chaudhari
Department of Pharmaceutics, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-411044, India.
Mahesh Pratapwar
Department of Pharmaceutics, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-411044, India.
Vishal Jadhav
Department of Pharmaceutics, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-411044, India.
Sarika Nikam
Department of Pharmaceutics, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-411044, India.
Fluconazole is antifungal drug act by inhibiting cytochrome P450 enzyme and found hydrophobic nature with dissolution related problems. On the account of few physico-chemical disadvantages, we performed work on a novel cinnamon oil based nanoemulsion drug delivery system. The drug-loaded formulation used cinnamon oil, Smix and water at a ratio of 15:30:55 v/v and was checked for various parameter of the internal system including conductivity and droplet size. The surfactant concentration was reduced to a great extent using sonicator as high energy method at a lab scale; that reduces of gastrointes tinal irritation. Also, sonication helps in the breakdown of coarse emulsion to fine droplets (nanoemulsion). The particle size reduction to about 65 ± 2.15nm as determined by dynamic light scattering technique would enable easy permeation through capillaries. Thus, we propose that the formulated system would serve as excellent oral drug delivery system for fluconazole.
7 , 2 , 2017
44 - 47