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DETERMINATION OF EFFECT OF MAGNESIUM STEARATE ON SILDENAFIL CITRATE TABLETS

V.SANDHYA
Department of pharmaceutics, Smt. Sarojini Ramulamma College of Pharmacy, Mahabub Nagar 509001, Andhra Pradesh, India.
N.SRI RAM
Department of pharmaceutics, Smt. Sarojini Ramulamma College of Pharmacy, Mahabub Nagar 509001, Andhra Pradesh, India.
VINAY UMESH RAO
Department of pharmaceutics, Smt. Sarojini Ramulamma College of Pharmacy, Mahabub Nagar 509001, Andhra Pradesh, India.

Sildenafil citrate ,Magnesium stearate ,Nitika ,Ferro ,Peter Grevens ,Mallinckordt ,

This study was carried out to determine the effect of different venders of manufactured Magnesium stearate (Nitika, Ferro, Peter Grevens, Mallinckordt) on the sildenafil citrate IR tablets properties like thickness, hardness, disintegration time and dissolution with a range of extra granular magnesium stearate from.0.5%, 1% 1.5 %.Here the amount of intragranular magnesium stearate was held constant. Sildenafil citrate tablets have been prepared by dry granulation method. Micro crystalline cellulose, Di basic calcium phosphate was used as diluents. Croscarmellose sodium was used as super disintegrant. Colloidal silicon dioxide as a glidant and magnesium stearate was used as lubricant. The analysis of the active constituents was followed by the study of drug release profile at various time points for all formulations and this profile of the formulation is correlated. This study concluded that the suitable vendor and % of magnesium stearate for the successful formulation

2 , 1 , 2012

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