FORMULATION AND EVALUATION OF FLOATING DRUG DELIVERY SYSTEM OF METFORMIN HYDROCHLORIDE AND PIOGLITAZONE HYDROCHLORIDE

M.Alekhya
Department of Pharmaceutical Analysis and Pharmaceutics, Nalla Narasimha Reddy Education Society’s and Group of Institutions, Hyderabad, India
N.Swapna
Department of Pharmaceutical Analysis and Pharmaceutics, Nalla Narasimha Reddy Education Society’s and Group of Institutions, Hyderabad, India
CH.Sirisha
Department of Pharmaceutical Analysis and Pharmaceutics, Nalla Narasimha Reddy Education Society’s and Group of Institutions, Hyderabad, India
CH.Gayathri
Department of Pharmaceutical Analysis and Pharmaceutics, Nalla Narasimha Reddy Education Society’s and Group of Institutions, Hyderabad, India
M.Anusha
Department of Pharmaceutical Analysis and Pharmaceutics, Nalla Narasimha Reddy Education Society’s and Group of Institutions, Hyderabad, India

Metformin hydrochloride ,Pioglitazone hydrochloride ,

The present study deals with the formulation and evaluation of floating drug delivery system using Metformin hydrochloride along with Pioglitazone hydrochloride as a bilayer tablet formulation for prolonged gastric residence time.Metformin hydrochloride and Pioglitazone hydrochlori de have been used as an oral hypoglycemic agent for control of diabetes. In this formulation metformin is sustained release layer and pioglitazone is immediate release layer. Sustained la yer was prepared by wet granulation method using different viscosity grades of HPMC ( HPMC K4M, HPMC K15M and HPMC K100M) as polymers and immediate release layer was prepared by direct compression method using superdisintegrants such as sodium starch glycolate and crosscarmellose sodium. The formulated tablets were subjec ted to various evaluation parameters including thickness, hardness, friability, weight variation, floating lag time, floating duration, drug content and in vitro dissolution studies. All the values were found to be within limit. The in-vitro dissolution studies were performed by USP-II type paddle apparatus in 900 ml 0.1 N HCl medium (P H -1.2) at 50 rpm and 37+0.5 0 C. The result showed that combinations of polymers namely HPMC K100M and HPMC K4M in sustained layer can control the release of drug. Simultaneou s estimation method was used to calculate drug release. Formulated tablets remain buoyant over a period of 10 hrs and released more than90 % of drug in study period.

4 , 4 , 2014