FORMULATION AND EVALUATION OF PIOGLITAZONE HCL MICROSPHERES PREPARED BY SIMPLE W/O EMULSIFICATIONCROSS LINKING TECHNIQUE
N. Sriram
Department of Biotechnology, Acharya Nagarjuna University, Guntur, India
Prakash Katakam
Department of Pharmaceutics, Nirmala College of Pharmacy, Mangalagiri, Guntur, Andhra Pradesh, India
Microencapsulation and mucoadhesion techniques were found acceptable to achieve controlled release and drug targeting for many years. Mucoadhesion facilitates the intimate contact of the dosage form with the underlying absorption surface for improved bioavailability of drugs to prolong the intestinal residence time. The present study involves preparation and evaluation of mucoadhesive pioglitazone HCl microspheres for improving the drug bioavailability by prolonged effect with reduced fluctuations in drug plasma concentration levels. Due to side effects of Pioglitazone HCl a sustained release medication is required to get prolonged effect with reduced fluctuations in drug plasma concentration levels. Pioglitazone HCl microcapsules were prepared by simple w/o emulsification-cross linking method using Chitosan as a polymer and glutaraldehyde as a cross linking agent. Infrared spectroscopy, differential scanning calorimetric and X-ray diffraction studies proved the compositions were compatible without interaction between the drug and excipients. The prepared microcapsules were evaluated for various physical and release parameters. The resulted microcapsules were found to be discrete and spherical in scanning electron microscopy studies and free flowing in rheological studies. Microspheres containing Chitosan exhibited good mucoadhesive property in the in vitro wash-off test. In vitro drug release studies were carried out up to 18 hours and they followed zero-order release kinetics
1 , 1 , 2011
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