FORMULATION AND EVALUATION OF ORAL DISPERSIBLE TABLETS OF CEFIXIME

Devi Naga Jyothi G
Krishna Teja Pharmacy College, Chadalawada Nagar, Tirupathi - 517506, Andhra Pradesh, India
Uma Sankar K
Krishna Teja Pharmacy College, Chadalawada Nagar, Tirupathi - 517506, Andhra Pradesh, India
Alagu Sundaram M
Krishna Teja Pharmacy College, Chadalawada Nagar, Tirupathi - 517506, Andhra Pradesh, India
Jayachandra Reddy P
Krishna Teja Pharmacy College, Chadalawada Nagar, Tirupathi - 517506, Andhra Pradesh, India

Cefixime ,Dissolution ,Dispersible tablets ,Super disintegrants ,

Oral route of administration is the predominant and most preferable route for drug delivery. Importantly, it allows unassisted administration by the patient without the need for trained people. The present work was aimed at formulation development, evaluation of oral dispersible tablets of Cefixime. Dispersible tablets or kid tablets are now a day increasingl y used for formulating drugs for infants and children with better bioavailability. The study was projected to develop and characterize formulation and evaluation of oral dispersible tablets using direct compression and wet granulation techniques a nd to turn up at a standard formulation, which ultimately meets all criteria required for tablets during shelf life. DSC and TGA studies carried out to see possible drug excipients interaction. It is concluded that a oral dispersible tablet was successfu lly formulated using super disintegrants, which gave a disintegration time of 15 seconds and a hardness of 2.5Kg/cm2 and without any additional modification in manufacturing.

4 , 4 , 2014