PREPARATION AND CHARACTERIZATION OF MONOBENZONE GEL LOADED SOLID LIPID NANOPARTICLES

In the present research work, topical gel composed of solid lipid nanoparticles of monobenzone was prepare d to produce sustain release of monobenzone to produce whitening effect. Initially solid lipid nanoparticles were prepared by double emulsification solvent evaporation method by using lecithin. PVA and PEG-600 are used as emulsifiers. The prepared solid lipid nanoparticles were evaluated for particle size, shape, drug content, entrapment efficiency, zetapotential and in-vitro drug release. Of all the formulations developed formulation F9 have shown the desired results and is thus selected to prepare the gel. The gel loaded solid lipid nanoparticles were evaluated for pH and viscosity of the gel along with in-vitro drug release. It was found that gel loaded solid lipid nanoparticles were stable and the percentage of drug release was in a sustained manner for more than 24 hours.