FORMULATION AND EVALUATION OF pH-TRIGGERED IN SITU GELLING SYSTEM OF PRULIFLOXACIN

The aim of the present work was formulation and evaluation of in situ gelling system of prulifloxacin. Prulifloxacin is an antibacterial agent which exhibits rapid precorneal elimination and poor ocular bioavailability, when given in the form of conventional ophthalmic solutions. To overcome this, an attempt has been made to formulate pH-triggered in situ gelling system of prulifloxacin to provide sustained release of drug based on polymeric carriers that undergo sol -to-gel transition upon change in pH. The prulifloxacin in situ gelling system formulated by using pol y acrylic acid (Carbopol 940) in combination with hydroxyl propyl methyl cellulose (HPMC) which acted as viscosity enhancing agent. The developed formulation was stable, non-irritant and provided sustained release over 8-hour period and it is aviable alternative to conventional eye drops