EFFECT OF PERMEATION ENHANCERS FOR PIROXICAM TRANSDERMAL GEL BY INVITRO AND EXVIVO PORCINE SKIN STUDIES

The aim of the present study was to investigate the effect of Permeation enhancers on the In vitro, Ex vivo skin permeation and deposition of Piroxicam. Formulation of piroxicam hydrogel using various enhancers (TPGS, Transcutol-P, PEG 300, SLS, Urea and Peppermint oil) along with Natrosol 250M (Hydroxy Ethyl Cellulose) as a gelling agent was tried. Parameters such as the solubility studies using 7.4 pH PBS, Partition coefficient in n octanol/ 7.4 PBS, the In vitro drug permeation studies using 0.45? pore size semipermeable membrane were recorded. Ex vivo drug permeation studies using porcine pig skin were carried out as evaluation techniques in a modified Franz diffusion cell (FDC). The maximum Permeation coefficient of Piroxicam Gels with Transcutol-P as permeation enhancer (4.753±0.751 ?g/cm2/h) which were about two-fold higher than the control formulation. The comparative data collection of piroxicam drug diffused from in vitro and ex vivo porcine skin study showed significant role in penetration enhancers in topical gel formulations. In conclusion, this study has generated effect of penetration enhancers on transdermal permeation of NSAID’s across the barrier membrane (Skin).