A REVIEW ON GASTRO RETENTIVE DRUG DELIVERY SYSTEM

Gastro retentive drug delivery system is novel drug delivery system which has an upper hand owing to its ability of prolonged retaining ability in the stomach and thereby increase gastric residence time of drugs and also improves bioavailability of drugs. Gastro retentive drug delivery system has gained immense popularity in the field of oral drug deliver recently. It is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with conventional oral delivery, including poor bioavailability. Gastro retentive drug delivery system is one of the site-specific delivery for the delivery of the drugs either in stomach or intestine. This can be obtained by retaining dosage form in to stomach and drug is released in controlled manner to specific site either in stomach, duodenum or/and intestine. Apart from in vitro characterization, successful gastro retentive drug delivery system development demands well designed in vivo study to establish enhanced gastro retention and prolonged released drug especially in small animals like mice or rat. Reported in vivo studies with beagle dogs. Rabbits and human subjects are only handful in spite of large number of encouraging in vitro result.