DEVELOPMENT AND INVESTIGATIONS ON INSITU GELS OF ECONAZOLE

This oral candidiasis is common and under diagnosed in elderly and mainly in the people who were dentures and this can be avoided by taking good care of mouth regimens. It is the mark of systematic disease like diabetes mellitus and common immune compromised problem. Candidiasis is caused due to the infection fungus or candida in the oral cavity. The insitu field forming implants are grown in recent years which are parallel to the development of new protein therapeutics. This is caused by genomic information and final human genome mapping. A reduced dose results from avoiding of peaks and valleys and also enhancing patient compliance by reducing frequency application, shows potential benefits from the point of manufacturing view, in situ forms depot system offers the advantage because they are simply manufacture from polymers adapted for third approach. It is newer approach to improve easy buccal instillation residence time and prolong drug release. From the study conducted, the following conclusion were drawn the gels which was prepared by using the technique thermo reverse gelation with Econazole shown good antifungal activity by in vitro and showed sustained release.