A NOVEL CARRIER FORMULATION FOR TOPIRAMATE LIQUIDSOLID COMPACTS

Solubility of drugs is a major factor in the design of pharmaceutical formulations lead to variable oral bioavailability. The in vitro drug dissolution rates of such preparations were compared to those of conventionally prepared directly compressed tablets using a USP-II apparatus. A mathematical model has been introduced in order to calculate the precise amounts of the excipients (carrier and coating materials) needed to produce a free-flowing powder. Formation of a complex between the drug and excipients or any changes in crystalline of the drug could be ruled out using DSC and XRPD measurements