DESIGN AND OPTIMIZATION OF MUCOADHESIVE MICROSPHRERE FOR NASAL DELIVERY OF GALLIC ACID

The aim of the current research was to design and test mucoadhesive chitosan microspheres of gallic acid to deliver drugs intranasally to improve bioavailability and avoid first-pass metabolism. The water-in-oil (W/O) emulsion cross-linking technique was used to prepare microspheres using chitosan, a mucoadhesive polymer and glutaraldehyde, a cross-linking agent. The 260 nm ?max was confirmed by UV spectrophotometric analysis which made it possible to quantify the drug accurately. The microspheres that were already prepared were described in terms of particle size, production yield, entrapment efficiency, mucoadhesion, drug content, swelling index, and drug release in in vitro condition. The size of the particle was 10-28 µm and the yield of production was 84-94. The entrapment efficiency was over 77 which implies the efficient encapsulation. The optimized formulation (F3) had the most mucoadhesion (?72%), drug content (~92%), and sustained release. SEM analysis demonstrated that it had a spherical morphology with smooth surfaces and FTIR was used to identify compatibility between drug and polymer. The researchers conclude that the mucoadhesive microspheres are a potential method of nasal carriers of gallic acid with enhanced therapeutic efficacy