FORMULATION EVALUATION AND OPTIMIZATION OF AN ORAL IMMEDIATE RELEASE ANTIBIOTIC FORMULATION OF AMOXICILLINE

The aim of the study was formulation Evaluation and optimization of an oral immediate rel ease antibiotic formulation of Amoxicilline using magnesium stearate sodium starch glycolate povidone microcrystalline cellulose carboxy methylcellulose sodium either alone or combinations tablets were prepared by direct compression wet granulation and dry granulation method and evaluated for various physical parameters. Amoxicilline is the antibiotic, it is used in gram+ve and gram-ve bacteria the drug release studies were performed using USP apparatus type11, using o.1NHcl and pH 6.2 phosphate buffe r as dissolution medium. The drug release was dependent on the type and concentration of the polymer dosage forms were characterized for powder properties like angle of repose, bulk density tapped density, and tablet properties like content uniformity, weight variation and hardness and friability and thickness and in-vitro dissolutions studies. Nine formulations were taken. Grade A the wet granulation, direct compression, dry granulation method were found good the compressibility index showed in the flow powder is possible range. Grade B practically the flow of blend for both tra ils was found good as per angle of repose and hausner’s ratio. Grade C according to the angle of repose the flow blen all trails good except trail 1. In sele ction of API the Grade C API was selected for the formulation by using dry granulation is showed poor flow by direct compression it also reduce the process loss and increase the productivity the selection of the granulation technique dry granulation showed the satisfactory result in this method no flow problem occurred and all the physical parameters ob served