AN OVERVIEW ON TECHNIQUES IMPLEMENTED FOR SUSTAINED RELEASE MATRIX TABLET OF GLIPIZIDE

Glipizide is one of the most commonly used anti-diabetic drugs for treatment of type 2 diabetes mellitus. It is effective in pancreatic secretion of insulin. Glipizide is used for patients with type 2 diabetes who have failed diet and exercise the rapy and it appears to be the most effective in first phase insulin secretion. Glipizide have short biological half -life i.e. 2 to 5 hrs, and is rapidly eliminated, so requiring it to be administered in 2 to 3 doses of 2.5 to 15mg per day. Hence once daily sustained release matrix tablet of glipizide is developed. Many methods are used for preparing sustained release preparations of glipizide. The review article comprises of the research materialized in the field of sustained release tablets of glipizide.