FORMULATION DEVELOPMENT OF IMMEDIATE RELEASE METOPROLOL TARTRATE TABLETS

The main objective of the present study was to formulate stable immediate release Metoprolol tartrate tablets matching in invitro dissolution with the marketed formulation. Tablets were manufactured by wet granulation method. Trials were taken with different superdisintregrants in different concentrations and the dissolution profiles were compared with that of marketed formulation. It was found that the dissolution profile of Metoprolol tartrate tablets, trial T7 which was formulated with Croscarmellose sodium 2% intragranular and 2% extragranular was similar to marketed formulation. The 50mg strength was formulated by common blend approach, with formula similar to optimized formula of 100mg tablets. The dissolution profile of 50 mg strength was compared with 100mg strength and the results were found to be satisfactory.