FORMULATION AND EVALUATION OF NIOSOMAL DRUG DELIVERY SYSTEM FOR FLUTAMIDE FOR THE TREATMENT OF PROSTATE CANCER

The current investigation were aimed to develop sustain release formulation of Flutamide niosomes in order to provide better therapeutic effect. Flutamide niosomes was prepared by thin film hydration method using drug, span 60 and cholesterol in different ratios. The formulations were optimized from the above method with respect to vesicle shape, entrapment efficiency, drug content, compatibility studies and in vitro drug release. The FT-IR spectra shows the drug and excipients were compatible. The in vitro release studies indicates that all the formulation exhibits retarded release for 24 hrs and its release mechanism was followed by Higuchi order kinetics.