DESIGN, OPTIMIZATION AND EVALUATION OF VEE GUM BASED RANITIDINE FLOATING GRANULES USING D-OPTIMAL DESIGN FOR OPTIMIZATION.

Manjula Chella
Srinivasa Rao College of Pharmacy, P.M. Palem, Visakhapatnam, Andhra Pradesh 530041, India
R. Santosh Kumar
Srinivasa Rao College of Pharmacy, P.M. Palem, Visakhapatnam, Andhra Pradesh 530041, India

Floating Granules ,Floating Drug Delivery System ,Controlled Release ,Natural and Semi-Synthetic Polymers ,D-Optimal Design ,

Ranitidine is histamine H2 antagonist widely used in the treatment of gastric ulcer. It is suitable drug for gastro-retentive floating granules due to its short half life and poor absorption in lower gastro intestinal tract. In the present research work, D-optimal design was used for optimization of levels of independent variables (sodium bicarbonate, beeswax, ethyl cellulose and citric acid) on dependent variables 50 and time taken for 100% release in the formulations of ranitidine gastro-retentive floating granules with less experimentation. From the results it was concluded that sodium bicarbonate (10%), beeswax (20%) and ethyl cellulose (10%) and citric acid (0%) were favorable for formulation of gastro-retentive floating granules employing vee gum as release retardant.

7 , 1 , 2017