A REVIEW ON FORMULATION ASPECTS OF CONTROLLED POROSITY OSMOTIC PUMP TABLETS

Salini C
Salini C
Krishnapillai
Krishnapillai,
Reshma Fathima K
Reshma Fathima K

Controlled drug delivery, Hydrostatic Pressure, Osmotic agent, Osmosis, Semi Permeable Membrane, zero order. ,

CPOP is the extension of Elementary osmotic pumps a new innovation in oral controlled plasma drug delivery, avoiding fluctuations in drug concentration offering better drug utilization and patient compliance. Osmotic system release drugs at a constant rate, which is reliable. CPOP is sponge like in appearance, the drug after dissolution is released from the core by hydrostatic pressure and diffusion through pores created by dissolution of pore formers in the membrane. The hydrostatic pressure is created either by osmotic agent or by a drug or a tablet component after water is imbibed across the semipermeable membrane, the membrane after the formation of pores is permeable to both water and solutes. This delivery system gained wider acceptance as the drug released is independent of pH, physiological conditions of GIT and spatial controlled pattern over a long period by osmosis maintaining uniform blood concentration which is important for treatment of various chronic diseases.

8 , 1 , 2018