FORMULATION AND EVALUATION OF pH-TRIGGERED IN SITU GELLING SYSTEM OF PRULIFLOXACIN

B. Sai Chaitanya
Department of Pharmaceutics, Sathyabama University, Chennai, Tamil Nadu
G. Dharmamoorthy
Department of Pharmaceutical analysis, Seven Hills College Pharmacy, Tirupati
Satish Babu Kotha
Department of Pharmaceutical analysis, Sri Lakshmi Narasimha College of Pharmacy, Chittoor
G. Avinash Kumar Reddy
Departement of Pharmacognosy and Phytochemistry, Sree Vidyanikethan College of Pharmacy, Tirupati-517102
M.S. Siva Prasad
Department of Pharmaceutical analysis, Seven Hills College Pharmacy, Tirupati

In situ gel , Cabopol 940 ,pH based gels ,Prulifloxacin ,

The aim of the present work was formulation and evaluation of in situ gelling system of prulifloxacin. Prulifloxacin is an antibacterial agent which exhibits rapid precorneal elimination and poor ocular bioavailability, when given in the form of conventional ophthalmic solutions. To overcome this, an attempt has been made to formulate pH-triggered in situ gelling system of prulifloxacin to provide sustained release of drug based on polymeric carriers that undergo sol -to-gel transition upon change in pH. The prulifloxacin in situ gelling system formulated by using pol y acrylic acid (Carbopol 940) in combination with hydroxyl propyl methyl cellulose (HPMC) which acted as viscosity enhancing agent. The developed formulation was stable, non-irritant and provided sustained release over 8-hour period and it is aviable alternative to conventional eye drops

2 , 1 , 2012