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FORMULATION AND CHARACTERIZATION OF SIMVASTATIN NANOSUSPENSION

Lavanya A
Department of Pharmaceutics, Krishna Teja Pharmacy College, Chadalawada Nagar, Tirupati-517506, Andhra Pradesh, India
Nirmala M
Department of Pharmaceutics, Krishna Teja Pharmacy College, Chadalawada Nagar, Tirupati-517506, Andhra Pradesh, India
Chandra Sekaran VS
Department of Pharmaceutics, Krishna Teja Pharmacy College, Chadalawada Nagar, Tirupati-517506, Andhra Pradesh, India

Simvastatin ,Nanosuspension ,Nanoprecipitation ,Poloxomer ,Permiability ,

Simvastatin is a hyperlipidemic drug and acoording to Biopharmaceutical Classification System (BCS) it is a Class II drug i.e. the drug having low solubility and high permeability. The purpose of the present work was to enhance the solubility and dissolution rate of simvastatin by reducing the size of the particles i.e. prepared as nanosuspension by nanoprecipitation technique at laboratory scale. Prepared nanosuspension was evaluated for its particle size and In vitro dissolution study and characterized by FTIR studies, Drug content, Zeta potential, Scanning Electron Microscope and UV Spectrophotometric studies. The present work was done by using three different surfactants in three different concentrations. The rate of dissolution of the optimized nanosuspension was enhanced (98% in 30min), relative to compared with the marketed simvastatin (82% in 30 min), mainly due to the formation of nanosized particles. These results shown the method of preparation of simvastatin loaded nanosuspension significantly improved in vitro dissolution rate, and thus possibly enhance fast onset of therapeutic action as compared with marketed product

9 , 2 , 2019

78 - 82

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