PREPARATION AND EVALUATION OF CEFUROXIME AXETIL AS A FLOATING TABLET

Balasubramanian V
Professor, Department of Pharmaceutics, Jainee College of Pharmacy, Dindugal, Tamilnadu. Affiliated The TN Dr MGR Medical University, Chennai, Tamilnadu, India
Senthil Kumar K L
Principal, Sri Vijay Vidyalaya College of Pharmacy, Dharmapuri, Tamilnadu. Affiliated The TN Dr MGR Medical University, Chennai, Tamilnadu, India
Vijaya K
Dean, Ultra College of Pharmacy, Madurai, Tamilnadu. Affiliated The TN Dr MGR Medical University, Chennai, Tamilnadu, India

Floating Tablets ,Cefuroxime Axetil ,Beta-Lactum Anti-Biotic ,

In this work, we designed and developed a hydrodynamically balanced tablet of cefuroxime axetil to boost its bioavailability and therapeutic efficacy. Cefuroxime axetil belongs to the second generation of cephalosporin antibiotics and beta-lactum antibiotics. A direct compression method is used to prepare tablets. HPMC K15 M is the polymers used in direct compression, and Sodium alginate is used as a Mass increasing agent. Magnesium Stearate has been used as Lubricant. Using a dissolution apparatus with 0.1N Hcl as a medium, the formulation was evaluated in vitro for byoyancy and drug release studies. Based on the results of these studies, floating tablets containing 60 milligrams of HPMC K15 M and cefuroxime axetil are shown to provide a better option for controlling release and improving bioavailabilit

10 , 2 , 2020