A FAST-DISSOLVING TABLET FORMULATION AND EVALUATION OF VERAPAMIL DRUG
Chennaram. Prabhakr Reddy*, Nageshwar Rao B
KLR Pharmacy College, Paloncha, Bhadradri Kothagudem, Telangana-507511, India
The development of fast-dissolving tablets (FDTs) of verapamil was aimed at addressing the shortcoming of conventional oral preparations of the drug, including low bioavailability and slow absorption. Calcium channel blockers such as verapamil are associated with some problems such as low dissolution in water and high first-pass metabolism that reduces its effectiveness in treatment. The dissolution rate, bioavailability, and action onset are increased by the use of FDTs that are formulated using superdisintegrants such as Cross Povidone (CP), Cross Carmellose Sodium (CCS), and Sodium Starch Glycolate (SSG), which is absorbed across the buccal mucosa, bypassing the gastrointestinal tract. To develop the tablets, the direct compression technique was used and different assessment parameters including thickness, hardness, friability, wetting duration and uniformity of drug content were done. Formulation F8 (CP-10%) performed optimally, releasing 99.88% of drug in 10 minutes, and again in the same timeframe, as a consequence of first-order kinetics. The stability investigation established the stability of the formulation at different storage environments. These results indicate that FDTs that carry verapamil would offer a viable option as fast therapeutic intervention in acute cardiovascular issues
15 , 2 , 2025
79 - 88