ADVANCEMENTS IN THE DEVELOPMENT OF CAPTOPRIL FAST DISSOLVING TABLETS: FORMULATION STRATEGIES, ADDITIVES, AND PROCESSING TECHNIQUES FOR IMPROVED PATIENT ADHERENCE
Suriya Kumar MS*, Mullaikodi O, Rajalingam D, Gnanasekar N, Kannabiran V
Suriya Kumar MS*, Mullaikodi O, Rajalingam D, Gnanasekar N, Kannabiran V
The angiotensin-converting enzyme inhibitor medication called Captopril treats both hypertension alongside heart failure in patients. Rapid development of captopril fast dissolving tablets (FDTs) will improve patient adherence especially within pediatric and elderly groups because these populations struggle to take standard tablet medications. This review investigates the diverse strategies and additives along with processing methods which researchers applied for developing and testing captopril FDTs. The development of captopril fast dissolving tablets utilizes three main production techniques which combine direct compression with sublimation and lyophilization alongside superdisintegrant use of crospovidone and sodium starch glycolate and croscarmellose sodium to generate prompt disintegration and dissolution properties. The evaluation process requires examination of parameters before compression takes place. As an alternative dosage form captopril FDTs provide better drug availability together with convenience to patients and improved adherence levels. The therapeutic potential of captopril will receive increased optimization through contemporary formulation science innovations in delivery systems.
15 , 2 , 2025
41 - 46