FORMULATION AND EVALUATION OF NANOSUSPENSION OF APREPITANT BY WET MILLING TECHNIQUE

P. Durga Bhavani
Department of Pharmaceutics, NOVA College of Pharmacy, Vegavaram, Jangareddy Gudem, Andhra Pradesh, India
S. Venkata Ramana Reddy
R&D Hetero Labs Limited, Hyderabad, Andhra Pradesh, India
Laxmidhar Sahoo
Department of Pharmaceutics, NOVA College of Pharmacy, Vegavaram, Jangareddy Gudem, Andhra Pradesh, India
K. Harinadha Baba
Department of Pharmaceutics, NOVA College of Pharmacy, Vegavaram, Jangareddy Gudem, Andhra Pradesh, India

Nanosuspensions ,Aprepitant ,Wet Milling Technique ,

Poorly water-soluble drugs pose many problems in formulation in conventional dosage forms. One of the critical problems associated with those drugs is low bioavailability and erratic absorption. The problem is even more complex for drug s (belonging to BCS CLASS II) as they are poorly soluble in both aqueous and organic media, and for those drugs having a log P value of 2.Nanosuspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages. Techniques such as media milling and high pressure homogenization have been used commercially for producing nanosuspensions. The media milling process can successfully process micronized and non micronized drug crystals. The purpose of this investigation was to reduce the particle size of aprepitant by media milling technique and formulation and evaluation of nanosuspension of aprepitant

3 , 1 , 2013