A REVIEW ON DRUG TARGETTING TO BRAIN
Ankith Kumar Reddy B
Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati, Andhra Pradesh- 517 561, India
Subhashis Debnath
Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati, Andhra Pradesh- 517 561, India
M. Niranjan Babu
Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati, Andhra Pradesh- 517 561, India
Target delivery of drug molecules to brain is one of the most challenging research areas in pharmaceutical sciences. The blood-brain barrier (BBB) represents an insurmountable obstacle for a large number of drugs, including antibiotics, antineoplastic agents, and a variety of central nervous system (CNS)-active drugs, especially neuropeptides. Therefore, various strategies have been proposed to improve the delivery of different drugs to this tissue which includes liposomes, colloidal drug carriers, micelles, chimeric peptide technology, intranasal and olfactory route of administration and nanotechnology. This review deals in brief about the status of the BBB, different pathologies of brain like neurodegenerative, cerebrovascular and inflammatory diseases. The first part of this article aims to review the strategies developed to circumvent the BBB and deliv er drugs into the brain. The use of nanotechnology and liposomes are discussed which are crucial parts of this article as mainly used to target various CNS disorders. The later part of this article contains future aspects of brain drug targeting.
3 , 2 , 2013
110 - 117