FORMULATION AND EVALUATION OF TASTE MASKED SUSPENSION OF AZITHROMYCIN DIHYDRATE

Shaikh Nuzhat Begum
PG Department of Biotechnology, Yeshwant Mahavidyalaya, Nanded, 431602, Maharashtra, India.
Shivaji B. Chavan
Organic Chemistry Research Laboratory, Yeshwant Mahavidyalaya, Nanded, 431602, Maharashtra, India.
Mohammad A. Baseer
Organic Chemistry Research Laboratory, Yeshwant Mahavidyalaya, Nanded, 431602, Maharashtra, India.
Vaseem Baig MM
PG Department of Biotechnology, Yeshwant Mahavidyalaya, Nanded, 431602, Maharashtra, India.

Taste Masked Suspension , Azithromycin Dihydrate ,

The article describes strategy for masking the intensely bitter taste of Azithromycin Dihydrate (AZT) by using complexation with Kyron T-134. The resinates prepared with drug-Kyron T-134 ratio (1:3) at pH 8, gave maximum drug loading. Suspension containing, resinate showed more than 90% Invitro drug release within 45min. Prepared formulation showed good stability and retention of palatable taste. Thus, the “patient-friendly dosage form” of bitter drugs, especially for pediatric, geriatric, bedridden, and non cooperative patients, can be successfully formulated using this technology.

4 , 1 , 2014