AN OVERVIEW ON TECHNIQUES IMPLEMENTED FOR SUSTAINED RELEASE MATRIX TABLET OF GLIPIZIDE

Gedar Sushma
Seth G. L. Bihani S. D. College of Technical Education, Sri Ganganagar, Rajasthan, India.
Kataria Mahesh Kumar
Seth G. L. Bihani S. D. College of Technical Education, Sri Ganganagar, Rajasthan, India.
Bilandi Ajay
Seth G. L. Bihani S. D. College of Technical Education, Sri Ganganagar, Rajasthan, India.

Sustained release ,Diabetes ,Glipizide ,Matrix tablet ,Granulation method ,

Glipizide is one of the most commonly used anti-diabetic drugs for treatment of type 2 diabetes mellitus. It is effective in pancreatic secretion of insulin. Glipizide is used for patients with type 2 diabetes who have failed diet and exercise the rapy and it appears to be the most effective in first phase insulin secretion. Glipizide have short biological half -life i.e. 2 to 5 hrs, and is rapidly eliminated, so requiring it to be administered in 2 to 3 doses of 2.5 to 15mg per day. Hence once daily sustained release matrix tablet of glipizide is developed. Many methods are used for preparing sustained release preparations of glipizide. The review article comprises of the research materialized in the field of sustained release tablets of glipizide.

4 , 2 , 2014