FORMULATION OF ONDANSETRON ORODISPERSIBLE TABLETS

V.P.Pandey
Department of Pharmacy, Annamalai University, Annamalai nagar- 608002, Tamilnadu, India.
V.Ranjith Kumar
Department of Pharmacy, Annamalai University, Annamalai nagar- 608002, Tamilnadu, India.
S.R.Muralikrishna
Safetab Life Sciences, Puducherry-605107, India

Ondansetron ,orodispersible Tablet ,Superdisintegrants ,Flavoring agents ,

In order to assist patients having difficulty of swallowing and for better patient compliance orodispersib le tablets are prepared. Ondansetron, 5-HT 3 receptor antagonist used as antiemetic is tried for orodispersible tablet formulation in present study. Objective of study undertaken is to mask bitter taste of ondansetron and develop fast orally disintegrating tablets. It is found that judicious selection of proportion of sucralose, polyplasdone XL 10, sodium starch glycolate and cross carmellose sodium along with trusil orange, peppermint and trusil strawberry flavours are suitable for orodispersible tablet of ondansetron.

4 , 2 , 2014