SOLUBILITY ENHANCEMENT OF SIMVASTATIN BY LIQUISOLID COMPACT TECHNIQUE

Alay Prashanth Kumar
Department of Pharmaceutics, Prasad Institute of Pharmaceutical Sciences, Jangaon, Warangal, Andhra Pradesh, India

Simvastatin ,Liquisolid tablets ,Coating material ,Carrier material ,

The main objective of this study is to improve the dissolution and there by availability of Simvastatin by Liquid Compact Technique. The liquisolid tablets of Simvastatin were prepared by using various ratio carriers (Avicel PH-200) to Coating (Aerosil 200) material using PEG 400 as non volatile solvent. The prepared Liquisolid tablets were evaluated for hardness, friability, thickness, disintegration time. The dissolution profile of Simvastatin tablets were determines according to USP method and compared to that of conventional tablet. The formulated liquisolid system of Simvastatin exhibited acceptable flowability and compressibility. Tablets showed more than 90 % release within 20 minutes. Technique of Liquisolid tablet of Simvastatin which can be scaled – up industrially is promising approach for enhancing solubility and dissolution rate. This was due to increase in wetting properties and surface of drug available for dissolution.

4 , 2 , 2014