FORMULATION AND EVALUATION OF DUAL TRANSDERMAL PATCH CONTAINING METFORMIN HYDROCHLORIDE -METOPROLOL TARTARATE

Jeevanandham Somasundaram
Assistant Professor, Dept. of Pharmaceutics, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Ethiopia.

Metoprolol tartarate ,Metformin hydrochloride ,Dual transdermal patch ,Diabetic and Hypertension ,

Intend of this study is to formulate and evaluate dual transdermal pa tch containing Metformin hydrochloride and Metoprolol tartarate. Diabetes mellitus generally accompanied with major complications like Hypertension. These situations lead to most morbidity and mortality among middle-aged, older people. So to maintain the drug plasma concentration for prolonged period of time Dual transdermal patch is the choice of dosage form to control the Diabetes associated with major complication like hypertension. The choice of drug for type2 diabetes mellitus is Metformin hydrochlorid e and for Hypertension is Metoprolol tartarate. Dual Transdermal drug delivery systems are capable of controlling the rate of drug delivery, prolonging the duration of therapeutic activity. Thus it is predicted that Dual Transdermal drug delivery systems c an be designed to deliver drugs at appropriate period of time to maintain suitable plasma drug levels for desired therapeutic efficiency. The results from dual release Transdermal patch of Metformin hydrochloride with Metoprolol tartarate could perform better both therapeutically with good patient compliance by significant overcome of diabetes along with its complication especially hypertension.

4 , 3 , 2014