EFFECT OF BAICALIN-COPPER COMPLEX AGAINST CARBON TETRACHLORIDE-INDUCED HEPATIC INJURY IN MICE

Mo Hu
College of Pharmaceutical Sciences, Southwest University, Chongqing, China
Xiaoli Li
College of Pharmaceutical Sciences, Southwest University, Chongqing, China
Qin Du
College of Pharmaceutical Sciences, Southwest University, Chongqing, China
Xiaoyan He
College of Pharmaceutical Sciences, Southwest University, Chongqing, China
Kai Zhou
College of Pharmaceutical Sciences, Southwest University, Chongqing, China
Defeng Li
College of Pharmaceutical Sciences, Southwest University, Chongqing, China
Zhubo Li
College of Pharmaceutical Sciences, Southwest University, Chongqing, China

Baicalin ,Copper ,Carbon tetrachloride ,Hepatic injury ,Atomic absorption spectrometry ,

Baicalin is the major active constituent of medicinal herb Scutellaria baicalensis Georgi, which contains abundant trace elements, such as copper, zinc, et al.. Our previous study found that baicalin-copper complex (BA-Cu) was easily synthesized and showed efficient antimicrobial and anti-tumor activities. Hence, we presumed that BA-Cu should exist in Scutellaria baicalensis Georgi. The present study examined the effect of baicalin-copper complex on CCl 4-induced hepatic injury. Mice were treated intraperitoneally with CCl4 after intramuscular injection with BA-Cu (50, 100 mg/kg, respectively). CCl4 administration increased serum aminotransferases, liver index, and decreased superoxide dismutase. These changes were altered by preadministration of the mice with BA-Cu. The CCl4-induced pathological conditions, including hepatic cord degeneration and inflammatory infiltration, were significantly attenuated by BA-Cu. Besides, we investigated the contents of copper in the liver by graphite furnace atomic absorption spectrometry. These findings suggest that BA -Cu has potent hepatoprotective effect on CCl 4-induced hepatic injury in mice.

4 , 3 , 2014