DETERMINATION OF EFFECT OF POLYMERS ON SOLUBILITY OF POORLY WATER SOULBLE DRUG

Noor Ahmed VH
Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, Rangampet, Tirupati, Andhra Pradesh, India
Saleem Malik V
Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, Rangampet, Tirupati, Andhra Pradesh, India
Rafi B
Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, Rangampet, Tirupati, Andhra Pradesh, India
Venkaiah A
Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, Rangampet, Tirupati, Andhra Pradesh, India
Manohar
Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, Rangampet, Tirupati, Andhra Pradesh, India
Jameerullah
Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, Rangampet, Tirupati, Andhra Pradesh, India
Veeranjeneyulu
Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, Rangampet, Tirupati, Andhra Pradesh, India
Naga Sri ND
Lydia College of Pharmacy, Ethakota, Ravula palem, Andhra Pradesh, India
Soheib Afroz
Vaagdevi College of Pharmacy, Hanumkonda, Warangal, Telangana, India.
Zinab Parvez Hussain
Mallareddy College of Pharmacy, Misammaguda, Hyderabad, Telangana, India.

Ibuprofen ,COX-1 , COX-2 ,Beta-CD ,NSAID ,Treated Crystal ,Microcrystillisation , In-Vitro Release ,SLS ,

Ibuprofen is a widely used non-steroidal anti-inflammatory drug [NSAID] and well-tolerated analgesic. According to BCS classification Ibuprofen belongs to class – II having low solubility and high permeability. To enhance the solubility of poorly water soluble drugs various techniques are already in practices. Among those micronisation and crystillisation techniques are the finest solubility enhancement techniques. The scope of present research work is preparation and evaluation of micro crystals of ibuprofen by using different excipients to enhance the solubility of the drug molecule there by improved bioavailability is of major thing. Hence, here we use the technique of micronisation to enhance the solubility by reducing th e size of the drug molecules upon usage of different excipients. The reduction of particle size leads to a significant increase in the dissolution rate of the API, which in turn can lead to substantial increases in bioavailability. Prepared crystals are characterized by FTIR, DSC and SEM studies. No interaction between ingredients was confirmed by FTIR, DSC. And also crystals are evaluated for solubility studies, drug content, and Invitro dissolution studies. The overall results indicate that prepared crystals had enhanced solubility compared to ibuprofen pure drug. Crystals prepared with Beta-CD had shown appreciable enhancement of solubility.

5 , 2 , 2015