112COMPENSATORY STRATEGY ON TRANSDERMAL DRUG DELIVERY SYSTEMSTransdermal drug delivery has made an advance contribution to medical practice, but it has yet to fully achieve its potential as an alternative to the oral delivery and hypodermic injections. An important of a transdermal drug delivery route over other types of delivery systems such as oral, topical, intravenous, intramuscular, etc. is that the patch may essentially can provide a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoi r of medication or through body heat melting thin layers of medication embedded in the adhesive. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs. Transdermal delivery has many advantages over conventional modes of drug administrations, it thus avoids hepatic first pass metabolism and improves patient compliance. This approach of drug delivery is more permanent in case chronic disorders like hypertension which requires long term dosing to maintain therapeutic drug concentration. These systems are easy to apply and remove as when desired. Second-generation delivery systems using chemical enhancers, non-cavitational ultrasound and iontophoresis have also resulted in clinical products; the ability of iontophoresis to control delivery rates in real time provides added functionality. Third-generation delivery systems target their effects to skin‘s barrier layer of stratum corneum using microneedles, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound. Using these novels secondand third-generation enhancement strategies, transdermal delivery is poised to significantly increase impact on medicine. Pharmaceutical scientists are striving to add new deliverables to the short list of approved Transdermal products. The main aim and objective of Transdermal drug delivery system are topical administered medicaments in the form of patches that deliver drugs for systemic effect at a predetermined and controlled rate. Transdermal systems deliver drugs direct through the skinmehdinub@yahoo.comReview722017Transdermal Drug Delivery,Excipients,Skin Permeation,Membrane moderated systems, Adhesive diffusion controlled system,Micro reservoir system,Animal ModelMd. Mehdi Hasan,A.S.M.Aktar-Uz-Zaman,Md. Mohshin Islam,S.M. Nazrul Islam,Yousuf,Harun Ar RashidDepartment of Pharmacy, Faculty of Life Science, University of Development Alternative, Dhaka-1209, Bangladesh,Department of Pharmacy, Faculty of Health science, Northern University Bangladesh, Dhaka -1205, Bangladesh,Department of Pharmacy, Faculty of Life Science, University of Development Alternative, Dhaka-1209, Bangladesh,Department of Pharmacy, Faculty of Health science, Northern University Bangladesh, Dhaka -1205, Bangladesh,Department of Pharmacy, Faculty of Health science, Northern University Bangladesh, Dhaka -1205, Bangladesh,Department of Pharmacy, Faculty of Health science, Northern University Bangladesh, Dhaka -1205, Bangladesh