12SOLID LIPID NANOPARTICLES – A BRIEF REVIEWNanotechnology opens up new vistas of research in the development of novel drug delivery systems. These colloidal nanoparticles based on biodegradable and biocompatible polymeric systems have largely influenced the controlled and targeted drug delivery aspects. Nanoparticles loaded bioactive not only deliver the drugs to the specific organs within the body but t he delivery rate in addition can be controlled as being bystanders, burst controlled, pulsatile and modulated. Many leading small molecule drugs are lipophilic. Lipophiles, or poorly water soluble molecules, play a very important, beneficial role in numerous biological processes. A novel pharmaceutical, applications of lipophilic compounds have been demonstrated by scientists and, more research effort is focused to develop novel approaches that utilize Lipophiles to overcome most challenging pharmaceutical issues as they increasingly discover Lipophiles’ diverse capabilities in biological processes. Lipophilic delivery is a challenging in a venue of the pharmaceutical sciences. Upon introduction to aqueous biological environments, lipophilic molecules exhibit instability, food interactions, reduced bioavailability, non-specific targeting, and toxic effects that produce undesired immunogenic responses and reduced efficacy, So the Lipophiles must be formulated and delivered in a safe, efficacious, and cost effective manner. 40% of all poorly water soluble drug candidat es and are abandoned due to solubility, stability, and delivery issuespavan.gkcp@rediffmail.comReview212011Nanoparticles,Lipophiles,Microemulsions, Solid dispersionsB. Pavan Kumar,Sk. KarimullaDepartment of Pharmaceutics, Gokula Krishna College of Pharmacy, Sullurpeta, Andhra Pradesh, India,Department of Pharmaceutics, Gokula Krishna College of Pharmacy, Sullurpeta, Andhra Pradesh, India