143A REVIEW ON FORMULATION AND EVALUATION OF NANO EMULSIONS LIKE LANSOPRAZOLE AND ITS OPTIMIZATION TECHNIQUESThe drug delivery technology has certainly a new interest for drugs by providing them new life through their therapeutic targets. Nowadays, targeting drug delivery is the major problem which is being faced by the researchers. Lansoprazole is proton pump inhibitor which extensively degraded in acidic pH conditions. Lansoprazole Nanosponge exhibits idea characteristics for a controlled released dosage form. Negative charged and small particle size of lansoprazole Nanosponge had an important impact in controlled release Formulation in giving good therapeutic outcomes. Different routes for emulsification are studied and droplet size variation with HLB, water fraction and surfactant concentration is also reported. For nano-emulsions prepared by self-emulsification, there is a detailed work on optimization. We can conclude that lansoprazole is well suitable for treating gastric and other ulcer related with its reduced particle size and minimal side effects and concerning optimization in preparation of nano-emulsions by shear, an optimum shear or time shearing can exist if breaking and coalescence are competing phenomena during the process.lukky984@gmail.comReview1112021Drug delivery,Lansoprazole,Nanosponges,Particle size,OptimizationK Muni Raja Lakshmi1,Narravula Lakshmi Priya,Suma shreeDepartment of Pharmaceutics, Sri Venkateshwara University College of Pharmaceutical Sciences, Tirupati, Andhra Pradesh, 517502, India.Associate professor, Department of Pharmaceutics, Sri Venkateshwara University College of Pharmaceutical Sciences, Tirup,Department of Pharmaceutics, Sri Venkateshwara University College of Pharmaceutical Sciences, Tirupati, Andhra Pradesh, 517502, India.,Department of Pharmaceutics, Sri Venkateshwara University College of Pharmaceutical Sciences, Tirupati, Andhra Pradesh, 517502, India