154CONTROLLED RELEASE OF LAMIVUDINE WITH MATRIX TABLETS USING NATURAL AND SYNTHETIC POLYMERSIn this study, an effort has been made to produce Lamivudine Matrix porous tablets, which are porous in nature. Microcrystalline cellulose polymers of various grades and grades of hydroxypropyl methyl cellulose were employed in the production of this product. All of the formulations were created utilizing the direct compression technique on an 8-station rotary tablet punching machine with a 6mm punch and a 6mm punch. The combination of all of the formulas demonstrated excellent flow parameters, including angle of repose, bulk density, and tapped density. Post-compression characteristics of the manufactured tablets were found to be satisfactory, and they passed all quality control evaluation criteria within the specified tolerances. Among all the formulations, the F3 formulation demonstrated the highest percent drug release, 98.65 percent in 8 hours, and as a result, it is regarded to be the optimal formulation. HPMC K15M is included in the F3 formulation at a concentration of 20 mg per gmvedpurushoth@gmail.comResearch1212022Lamivudine,Cellulose,HpmcM. Purushothaman,K. Dharmaprakash,N. Venkatesh,J.SujithaDepartment of Pharmaceutics, Padmavathi College of Pharmacy, Peryanahalli, Dharmapuri, Tamil Nadu, India.,Department of Pharmaceutics, Padmavathi College of Pharmacy, Peryanahalli, Dharmapuri, Tamil Nadu, India.,Department of Pharmaceutics, Padmavathi College of Pharmacy, Peryanahalli, Dharmapuri, Tamil Nadu, India.,Department of Pharmaceutics, Padmavathi College of Pharmacy, Peryanahalli, Dharmapuri, Tamil Nadu, India.