158FORMULATION AND EVALUATION OF VITEX NEGUNDO AND ALOEVERA NANOGELNanogel formulations of Vitex negundo and Aloe vera were developed and included in the gel. The results of the present experiment indicate that formulation F7 shows high entrapment of Vitex negundo and Aloevera nanogel. The plot of the time versus concentration revealed that the optimized formulation F7 follows zero order release pattern. A sustained release of the optimized formulation from the nanogel formulation was observed for 12 hours. Nanogel preparation of the optimized formulation F7 was found to be antibacterial, thereby achieving the objectives of the project. Accordingly, medicinal plants that inhibit their growth without harming the host are potentially useful therapeutic agentsabisuryaah@gmail.comResearch1212022Formulation,Evaluation,Vitex Negundo,AloeveraAbirami A,Gunaseelan S,Mohamed Halith S,Hariharan A GProfessor and HOD, Department of Pharmaceutics, K.M.College of Pharmacy, Uthangudi, Madurai.,PG Scholar, Department of Pharmaceutics, K.M.College of Pharmacy, Uthangudi, Madurai,Principal, Dhanalakshmi Srinivasan College of Pharmacy, Perambalur,Professor, Department of Pharmaceutics, K.M.College of Pharmacy, Uthangudi, Madurai