160PREPARATION AND EVALUATION OF CEFUROXIME AXETIL AS A FLOATING TABLETIn this work, we designed and developed a hydrodynamically balanced tablet of cefuroxime axetil to boost its bioavailability and therapeutic efficacy. Cefuroxime axetil belongs to the second generation of cephalosporin antibiotics and beta-lactum antibiotics. A direct compression method is used to prepare tablets. HPMC K15 M is the polymers used in direct compression, and Sodium alginate is used as a Mass increasing agent. Magnesium Stearate has been used as Lubricant. Using a dissolution apparatus with 0.1N Hcl as a medium, the formulation was evaluated in vitro for byoyancy and drug release studies. Based on the results of these studies, floating tablets containing 60 milligrams of HPMC K15 M and cefuroxime axetil are shown to provide a better option for controlling release and improving bioavailabilitBalasubramanian@gmail.comResearch1022020Floating Tablets,Cefuroxime Axetil,Beta-Lactum Anti-BioticBalasubramanian V,Senthil Kumar K L,Vijaya KProfessor, Department of Pharmaceutics, Jainee College of Pharmacy, Dindugal, Tamilnadu. Affiliated The TN Dr MGR Medical University, Chennai, Tamilnadu, India,Principal, Sri Vijay Vidyalaya College of Pharmacy, Dharmapuri, Tamilnadu. Affiliated The TN Dr MGR Medical University, Chennai, Tamilnadu, India,Dean, Ultra College of Pharmacy, Madurai, Tamilnadu. Affiliated The TN Dr MGR Medical University, Chennai, Tamilnadu, India