22FORMULATION AND EVALUATION OF NANOSUSPENSION OF APREPITANT BY WET MILLING TECHNIQUEPoorly water-soluble drugs pose many problems in formulation in conventional dosage forms. One of the critical problems associated with those drugs is low bioavailability and erratic absorption. The problem is even more complex for drug s (belonging to BCS CLASS II) as they are poorly soluble in both aqueous and organic media, and for those drugs having a log P value of 2.Nanosuspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages. Techniques such as media milling and high pressure homogenization have been used commercially for producing nanosuspensions. The media milling process can successfully process micronized and non micronized drug crystals. The purpose of this investigation was to reduce the particle size of aprepitant by media milling technique and formulation and evaluation of nanosuspension of aprepitantspoorthiombhavani@gmail.com Review312013Nanosuspensions,Aprepitant,Wet Milling TechniqueP. Durga Bhavani,S. Venkata Ramana Reddy, Laxmidhar Sahoo, K. Harinadha BabaDepartment of Pharmaceutics, NOVA College of Pharmacy, Vegavaram, Jangareddy Gudem, Andhra Pradesh, India,R&D Hetero Labs Limited, Hyderabad, Andhra Pradesh, India,Department of Pharmaceutics, NOVA College of Pharmacy, Vegavaram, Jangareddy Gudem, Andhra Pradesh, India,Department of Pharmaceutics, NOVA College of Pharmacy, Vegavaram, Jangareddy Gudem, Andhra Pradesh, India