30FORMULATION AND EVALUATION OF NATURAL GUM BASED ESOMEPRAZOLE SUSTAINED RELEASED TABLETSEsomeprazole is a proton pump inhibitor used in dyspepsia .The approach of the present study was to make a comparative evaluation among concentration of Natural polymers like xanthum gum, guar-gum and pectin and to assess the effect of physico-chemical nature of the active ingredients on the drug release profile. The angle of repose, compressibility index and sieve analysis results shown that the formulation is suitable for direct compression. This study have been showed that Esomeprazole could be used in sustained release drug delivery system by formulating it has sustained drug delivery system, provides extended duration of action in therapeutic range without reaching toxic levels as in the case of conventional dosage forms. These dosage forms have the ability to reduce the dosing frequency and increasing. The technique employed in the preparation of matrix system i.e. direct compression, is highly practical and economical from the industry point of view. The sustainability of the drug with Guar gum as a sustaining polymer at a concentration of 40 mg was found to show good sustainability when compared to the marketed formulation. Success of the In vitro drug release studies recommends the product for further In vivo studies, it may improve patient compliancesrinivasulupharma2k7@gmail.com Research322013Esomeprazole,Guar gum,Sustaining polymer,TabletsSrinivasulu M,Hindusthan Abdul Ahad,Venupriya RDepartment of Industrial Pharmacy, Balaji College of Pharmacy, Ananthapur, Andhra Pradesh, India.,Department of Industrial Pharmacy, Balaji College of Pharmacy, Ananthapur, Andhra Pradesh, India.,Department of Industrial Pharmacy, Balaji College of Pharmacy, Ananthapur, Andhra Pradesh, India.