32DESIGN DEVELOPMENT AND EVALUATION OF NOVEL NANOEMULSION OF SIMVASTATINSimvastatin is a synthetic anti hyperlipidemic drug which will solubilize the low density lipids accumulated in the arteries. Simvastatin is a lipophilic drug thus results in the poor bioavailability after oral administration. Therefore the clinical efficacy of these drugs is sometimes not realized. Therefore nanoemulsion containing Simvastatin was prepared with a view to increase its bioavailability. The pseudo-ternary phase diagrams were developed using the aqueous titration method. Surfactant (Tween 80) and co-surfactant (Ethanol) were mixed(Smix) in different volume ratios (1:1, 1:2, 1:3, 1:4, 2:1, 3:1, 4:1). Isop ropyl myristate optimized as an oil phase based on the solubility study. For each phase diagram, oil (olive oil) and specific smix ratios were mixed thoroughly in different volume ratios from 1:7 to 7:1. Different combinations of oil and smix (1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 2:1, 3:1, 4:1, 5:1, 6:1, 7:1) were made for the study to delineate the boundaries of the phases precisely form ed in the phase diagrams.The formulated nanoemulsions has to be evaluated for drug release, viscosity, surfactant concentration, electro conductivity and TEM analysisankithpharmaline0002@gmail.com Research322013Simvastatin,Nanoemulsion,Surfactant,oil,Co-surfactantAnkith Kumar Reddy B,Subhashis Debnath,M. Niranjan BabuDepartment of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati, Andhra Pradesh- 517 561, India,Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati, Andhra Pradesh- 517 561, India,Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati, Andhra Pradesh- 517 561, India