46FORMULATION AND EVALUATION OF TIZANIDINE HYDROCHLORIDE TRANSDERMAL PATCHESTransdermal patches were prepared with the objective of avoiding hepatic first pass effect and gastric disturbances associated with tizanidine and reduce the dosing frequency compared with the oral route and also to provide ease of administration. The transdermal patches containing tizanidine HCl were prepared using different ratios of hydroxypropyl methyl cellulose and polyvinyl pyrrolidine. The prepared films were subjected to different physicochemical evaluations and ex vivo permeation study. From the results of diffusion study formulation F5 was found to be satisfactory proiding drug release for period of 12 hours and hence revealing that transdermal patches made of HPMC and PVP are promising polymers for the preparation of transdermal patches in overcoming the disadvantages of oral route.sandhyaguggilla9@gmail.comResearch412014Transdermal,Formulation,Hydroxyl propyl methyl celluloseSandhya Rani G,Supraja N,Ratnakar ADepartment of Pharmaceutics, Vaageshwari College of Pharmacy, Thimmapur, Karimnagar Dist.-505481, Andhra Pradesh, India,Department of Pharmaceutics, Vaageshwari College of Pharmacy, Thimmapur, Karimnagar Dist.-505481, Andhra Pradesh, India,Department of Pharmaceutics, Vaageshwari College of Pharmacy, Thimmapur, Karimnagar Dist.-505481, Andhra Pradesh, India