55EVALUATION OF ANTITUSSIVE ACTIVITY OF FORMULATED HERBAL COUGH SYRUPFormulated syrup of Cochlosperum vitifolium was investigated for antitussive effect on citric acid induced cough model in guinea pig. The results showed that the formulated cough syrup exhibited significant antitussive activity in a dose dependent manner the activity was compared with the prototype antitussive agent diphenhydramine HCl. It has been observed that the extract has produced 60%, 80%, 90% reduction in cough bouts at the dose level of 2, 4, 6 ml respectively after 1hr o f drug administration. It is evident from the data the highest dose of 6 ml was found to be more effective. It is found that antitussive activity produced by the herbal formulation in the minimum dose was much better than the standard drug .sumapharm73@gmail.comResearch422014Antitussive agent,herbal cough syrup,Diphenhydramine HCl, Citric acid inducedP. Sumathy,P. Sucharitha,P. SandhayaDepartment of Pharmaceutics, Sri Venkateswara College of Pharmacy, R.V.S.Nagar, Chittoor - 517 127, Andhra Pradesh, India.,Department of Pharmaceutics, Sri Venkateswara College of Pharmacy, R.V.S.Nagar, Chittoor - 517 127, Andhra Pradesh, India.,Department of Pharmaceutics, Sri Venkateswara College of Pharmacy, R.V.S.Nagar, Chittoor - 517 127, Andhra Pradesh, India.