57FORMULATION AND EVALUATION OF TRIPLE DRUG COMBINATION OF OLMESARTAN MEDOXIMAL, AMLODIPINE BESYLATE AND HYDROCHLOROTHIAZIDE TABLETSThe purpose of the present study is to investigate the triple drug combination of Anti-hypertensive drug for the improvement of patient compliance while treating hypertensive patients. The interaction between drug and excipients was studied using FTIR. The results of FTIR study revealed that all three drugs with exc ipients were found compatible. The tablets were prepared by wet and direct compression method using various diluents. The prepared formulations were evaluated for varies parameters like Hardness, Friability, Disintegration time. Tablets were subjected to In vitro drug release studies using pH 6.8 phosphate buffer and 0.1N HCl as a dissolution medium. The Hardness, friability and DT of tablet was found 4 to 5 kg/cm 2 , 0.22 to 0.3%, 3 to 4 minutes respectively. The dissolution profile of the tablet revealed t hat all three drugs were released more than 90% within 30 minutes. The stability study was performed as per ICH guidelines. Optimized F6 formulation was packed in blister and kept at 25°C and 40°C, 60 ± 5% RH and 75% ± 5% RH for 3 months. At end of the study period, there is no significance change in the formulation was observed. Hence, it is finally concluded that these triple drug formulation could be used for hypertension and it can be considered as one of the promising fixed drug dosage formkarunaspharma@yahoo.comResearch422014Olmesartan Medoximal,Amlodipine besylate and Hydrochlorothiazide,Fixed drug dosage form,AntiHypertensiveKaruna DS,Sowjanya L,Ubaidulla Udhumansha,Grace RathnamDepartment of Pharmaceutics, C.L.Baid Metha College of Pharmacy, Chennai-97, Tamilnadu, India.,Department of Pharmaceutics, C.L.Baid Metha College of Pharmacy, Chennai-97, Tamilnadu, India.,Department of Pharmaceutics, C.L.Baid Metha College of Pharmacy, Chennai-97, Tamilnadu, India.,Department of Pharmaceutics, C.L.Baid Metha College of Pharmacy, Chennai-97, Tamilnadu, India.