65FORMULATION OF BILAYERED TABLET OF LOSARTAN POTASSIUM AND AMLODIPINEIn the combined formulation of amlodipine and losartan, amlodipine may be locked in inside of the formulation due to gelation of losartan and formulation with simple mixing of two have very poor storage stability. To avoid such problem, bilayer tablet of losartan and amlodipine is tried in present study. Five formulati ons (F1, F2, F3, F4 and F5) of bilayer tablet were prepared and evaluated for physical parameters and in vitro study. One bilayer tablet formulation (F5) was found suitable in evaluation. It was subject to stability study for 45 days at 25 o C/ 60 % RH as per ICH guidelines and found stable.vppnp@rediffmail.comResearch432014Losartan potassium,Amlodipine,Bilayered tablet,Antihypertensive.V.P.Pandey,R.Sathish Kumar,A.Sathish BabuDepartment of Pharmacy, Annamalai University, Annamalainagar – 608002, Tamilnadu, India,Department of Pharmacy, Annamalai University, Annamalainagar – 608002, Tamilnadu, India,The Madras Pharmaceuticals, Karapakkam. Chennai – 600096, Tamilnadu, India